LSD is one of the most well-known and culturally influential psychedelic substances. LSD, also known as “acid” is an abbreviation from the chemical name of the molecule in German Lysergsäure-diethylamide (in English: lysergic acid dimethylamine). It is a basic chemical structure found in the ergot alkaloids of the grain fungus ergot. Although LSD is produced in a laboratory, it’s semi-synthetic since the raw material is found in nature. Sometimes it’s considered to be the first modern entheogen, a category that is otherwise limited to traditional earth medicines such Magic Mushrooms San Pedro, and Ayahuasca.
The main reasons why people choose to microdose with LSD, include:
- It’s sometimes more readily available than other substances; this is especially true outside of Europe
- It has been in circulation for decades, and there is a fair amount of scientific research since the 1950s; thus, we are aware of the effects (in high doses).
- People experience the effects and method of ingestion as more pleasant than with other substances. However, this is highly subjective. That’s why you should listen to your own body and trust your own experience when microdosing LSD.
Misconceptions about LSD
First, let’s clear up some misconceptions about LSD:
- LSD doesn’t cause chromosomal abnormality or developmental defects in humans
- No fatal overdoses from LSD have been reported. Not even at extremely high doses!
- The use of LSD and other psychedelics does not constitute an independent risk factor for mental health problems and psychosis
- LSD is not physically addictive, and no physical withdrawal symptoms occur after us
- There is no strychnine or rat poison in LSD
- You don’t get ‘stuck in a trip or ‘permatripping’. Leading scientists agree that there is no evidence for the existence permatripping.
History of LSD
Swiss chemist Albert Hofman first synthesized LSD in 1938 but only (accidentally) discovered its psychoactive effects on April 19th, 1943. At the laboratory in Basel where he was working at the time, he ingested what’s in pharmacology considered a tiny amount of the substance, namely 250 micrograms (this turned out to be what nowadays is called a macrodose of LSD). He started to feel a bit disoriented, so he biked home, where he was the first person ever to experience the intense hallucinogenic effects of LSD. Psychonauts now commemorate the discovery day and the first “acid trip” annually on April 19th as Bicycle Day.
In the 1950s, LSD was used as an experimental drug in psychotherapy and scientific research, mainly to treat anxiety, depression, addiction, and psychosomatic disorders. (Psycho‐) pharmacological research on LSD was extensive and produced nearly 10,000 scientific papers. In the following years, the interest for the new substance grew wide-ranging from medical professionals, scientists, and even the US government. The infamous CIA program code-named MK ULTRA investigated using LSD for ‘mind control’ and chemical warfare. CIA employees, military people, doctors, prostitutes, mentally ill patients, and members of the public were all given LSD without their knowledge or agreement, resulting in at least one death.
In the 1960s, LSD played a central role in the counter culture movement due to its consciousness-expanding properties, eventually leading to its prohibition in 1971. After nearly 10,000 publications of scientific papers on LSD, the extensive research came to an abrupt stop. The last FDA-approved study with LSD was conducted in 1980, and for nearly forty years, further research into the effects and potential benefits of LSD lay dormant.
Finally, in 2016, The Beckley/Imperial Research Programme published the world’s first images of the human brain on LSD, revealing some of the fundamental mechanisms behind its profound consciousness-altering effects. Today, many people worldwide have greatly benefitted from using this substance through therapeutic journeys or, more recently, by microdosing LSD.
Legality of LSD
Worldwide, LSD is listed as a Schedule 1 drug, which means that it’s considered to have “no currently accepted medical use and a high potential for abuse“. Nevertheless, medical and scientific research with LSD in humans is allowed under the 1971 UN Convention, although it has been extremely challenging to carry out in practice.
Regardless of its legal status, many people still decide to microdose with LSD. Therefore, we believe it’s essential to provide reliable information about microdosing LSD. It’s up to you to make a well-considered choice while being fully aware of the risks. If you don’t want to take any risks regarding the legality, choose decriminalized substances, such as magic mushrooms in Oregon (and other US states to follow) and magic truffles in The Netherlands. LSD is available in the underground circuit in liquid or as a blotter (paper strip). With the latter, liquid LSD has already been dripped onto a piece of paper.
The effects of LSD
LSD is the most potent psychedelic that exists. The fact that the dose measured in micrograms (one-thousandth of a milligram) says it all. It’s taken orally via a paper trip that is placed on or under the tongue or swallowed. Under the tongue, it works faster than when swallowed. When swallowed, you notice the effects after 30 to 90 minutes. You notice the effects sooner when placed under the tongue because it’s absorbed directly through the oral mucosa.
An LSD trip lasts on average eight to twelve hours, but depending on your sensitivity, it can last longer. Like other psychedelics, LSD is not addictive. In a light trip, you are high and maintain a certain degree of control and overview. With a heavy trip, this disappears, and there is no more control. The trip goes in waves. Thinking is highly associative and seems to go in circles.
An LSD trip is a highly intense experience, and it’s not something most people want to do regularly. However, people commonly report mystical-type experiences that can facilitate self-reflection and personal growth. In addition, you cannot use LSD for days in a row because tolerance increases so quickly that trip effects no longer occur. The habituation or tolerance also builds off just as quickly.
As a result, users wait several weeks or months before using LSD again. Therefore, the chance of addiction is hardly there. However, people can become mentally dependent on the tripping experience itself (and not the substance) in more exceptional cases. These are usually people who also take many other mind-altering drugs. In essence, mental dependence is possible with anything.
The subjective effects of high doses include:
- Visuals (both with eyes open and closed)
- Time distortions
- Increased introspection
- Conceptual thinking
- Ego loss
Pharmacology of LSD
The pharmacology of LSD is complex, and its mechanisms of action are still not completely understood. However, we know that LSD works on the serotonin receptors in the brain, which causes euphoria in most people.
Toxicity & risks of LSD
Unlike other highly prohibited substances, no one has proven that LSD is physiologically toxic or addictive. However, adverse psychological reactions can happen to people predisposed to psychological or psychiatric disorders.
The most considerable risk lies in people selling other substances as LSD, including more potent and harmful substances such as DOB or 25i-NBOMe. However, this rarely happens, and you can completely eliminate this by testing the LSD at either a testing service or with an LSD test kit.
When microdosing LSD, people usually take 1/20 to 1/10 of a 100 micrograms paper trip. This means a microdose of LSD is usually between 5 and 10 micrograms. However, the amount of LSD needed may vary per time and person, depending on physical and mental condition, gut biome, environment, and potency of the LSD. Therefore we advise against blindly taking the same microdose as someone else; rather start low and go slow to find your ideal dose (sweet spot). Additionally, LSD blotters come in different strengths, and there it’s crucial to determine how many micrograms of LSD your blotter contains.
NOTE: Many first-time microdosers think they had found an easy solution: cut the blotter into 10 or 20 equal pieces (although the piece of paper can be tiny). We advise against this. It’s unlikely the LSD is evenly distributed over the blotter. So, in reality, some of your microdoses will be mini doses and other less than a microdose.
Effects of microdosing LSD
The threshold level (the amount at which people start to notice a mild psychedelic effect) varies but is usually between 10 and 50 micrograms. The (sub-perceptual) effect of a microdose of LSD can last for up to 10 hours, which makes the time of ingestion especially important. We recommend that to take your LSD microdose before 10:00 AM. If you want to have a shorter experience, consider microdosing with magic mushrooms.
When microdosers describe their experiences with LSD, they often report an increase in creativity, energy, problem-solving capacity, and focus. Nonetheless, like with all psychedelics, we believe this is a subjective experience. Additionally, LSD is a non-specific amplifier, meaning that, for example, your creativity may emerge when you work with art or music. But, if you choose to have a good conversation with a loved one, there might be more emphasis on connection, reflection, or emotions.
Risks of microdosing LSD
The health risks of taking LSD are mostly psychological rather than physiological. LSD is not dangerous to the body or brain itself, but can pose psychological risks. In fact, LSD is one of the safest psychoactive substances because the difference between an active dose and an overdose is very large. Where one takes around 100 micrograms to trip, the LD50 (lethal dose for 50% of the test animals) is estimated to be more than 1000 times higher.
As far as modern science knows, LSD doesn’t cause damage to the body in both short and long term, and after 24-48 hours all the substance needed for one trip is completely removed from the body. Physical overdose is therefore almost impossible, but that doesn’t mean that microdosing LSD– like many activities –completely risk-free.
One potential concern is found for microdoses of LSD in people with pre-existing heart conditions, which comes from studies demonstrating that fenfluramine, when taken daily, doubles the risk of Valvular Heart Disease. Fenfluramine binds to the same receptors as LSD and psilocybin, but the quantities used for microdosing are extremely low in comparison. More research is needed to know if this potential risk effectively translates to humans who microdose with LSD. The current stance in science is that the microdosing protocols of 10-weeks, with a 4-week pause afterwards, are sufficiently protective for microdosers. If you have a pre-existing heart condition, it’s advised to avoid extended periods of microdosing.
How to prepare your dose for microdosing LSD—volumetric dosing
Ensure you get identical dosages for microdosing LSD and avoid the risk of your dosages being too high or too low; use the volumetric dosing method.
What you need:
- Pipette bottle
- 1-milliliter syringe
- A solvent. Either distilled/demineralized water or pure ethanol or alcohol (IMPORTANT: Don’t use tap water, it contains chloride, which destroys LSD, as well as the well-known analogs such as 1P-LSD & 1cP-LSD)
- LSD (or 1P-LSD & 1cP-LSD) blotters
- An LSD test kit
If you are in the European Union, you can order a set for volumetric microdosing here (without the active substance).
Steps for volumetric dosing:
- Test your LSD with the LSD test kit
- Inject 10 milliliters of distilled water or alcohol into the pipette bottle
- Put the LSD blotters into the bottle with the liquid (we advise putting 200 micrograms of LSD into the liquid to make measuring, later on, more manageable. This means if you have blotters of 100 micrograms, you put two blotters per 10 milliliters)
- Let the blotters soak for at least 24 hours
- Once in a while, shake the bottle gently.
- If your bottle is transparent, wrapped some tin foil around it (IMPORTANT: LSD breaks when exposed to (UV) light)
- Store the bottle in a cool place
- It will last for four to ten weeks microdosing LSD
How to accurately measure your LSD microdose
A microdose of LSD is between 5 and 10 micrograms (depending on your sweet spot). It’s important to note the difference in fluidity between distilled water and alcohol. Additionally, it’s vital for you to know how many micrograms are on the blotter, then you can calculate how many micrograms are in 1 drop in the following way:
With distilled water
10 milliliters of distilled water translates into exactly 200 drops. If you put 200 micrograms into the bottle, 1 drop = 1 microgram LSD (if you only put 100 micrograms, 2 drops = 1 microgram LSD).
Take between 5-10 drops (or 10-20 drops if you put only 100 microgram LSD) depending on your sweet spot.
10 milliliters of alcohol translates into exactly 400 drops of alcohol. If you put 200 micrograms into the bottle, 2 drops = 1 microgram LSD (if you put only 100 microgram LSD, 4 drops = 1 microgram LSD)
Take between 10-20 drops (or 20-40 drops if you only put 100 microgram LSD) depending on your sweet spot.
Another option: research chemicals
To ensure that you microdose 100% accurately, research chemicals can be a safer option. These substances are produced legally in a lab, which guarantees the potency they indicate. In contrast, LSD is being sold on the black market; a vendor will often tell you their supply is more potent than it is. Our partner shop sells ready-to-use 1cP-LSD bottles for microdosing (EU customers only).
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- Convention On Psychotropic Substances, 1971. United Nations Office on Drugs and Crime. Retrieved January 3, 2020.
- Joint Hearing before the Select Committee On Intelligence and the Subcommittee On Health And Scientific Research of the Committee On Human Resources: Ninety-fifth congress: First Session”. U.S. Government Printing Office. August 3, 1977. Retrieved January 3, 2020.
- Schmid, Y.; Enzler, F.; Gasser, P.; Grouzmann, E.; Preller, K. H.; Vollenweider, F. X.; Brenneisen, R.; Müller, F.; Borgwardt, S.; Liechti, M. E. (2015). “Acute Effects of Lysergic Acid Diethylamide in Healthy Subjects”. Biological Psychiatry. 78 (8): 544–553.
- Zentner, Joseph L. (1976). “The Recreational Use of LSD-25 and Drug Prohibition”. Journal of Psychedelic Drugs. 8 (4): 299–305.
Passie, T, Halpern, J.H., Stichtenoth, D.O., Hinderk, M., & Hintzen, A. (2008) The pharmacology of lysergic acid diethylamide: a review. CNS Neurosci Ther. 14(4).